6WSI

Intact cis-2,3-epoxysuccinic acid bound to Isocitrate Lyase-1 from Mycobacterium tuberculosis

Summary for 6WSI

• Entry DOI: 10.2210/pdb6wsi/pdb
• Descriptor: Isocitrate lyase, MAGNESIUM ION, GLYOXYLIC ACID, ... (7 entities in total)
• Functional Keywords: enzyme, covalent inhibitor, substrate analog, structural genomics, psi-biology, tb structural genomics consortium, tbsgc, lyase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 191284.25

Authors

Krieger, I.V.,Mellott, D.,Meek, T.D.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2020-05-01, release date: 2021-03-24, Last modification date: 2023-10-18)

• Primary citation: Pham, T.V.,Mellott, D.M.,Moghadamchargari, Z.,Chen, K.,Krieger, I.,Laganowsky, A.,Sacchettini, J.C.,Meek, T.D.; Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis -2,3-Epoxy-Succinic Acid.; Acs Chem.Biol., 16:463-470, 2021; PubMed: 33688722; DOI: 10.1021/acschembio.0c00740

Experimental method

X-RAY DIFFRACTION (1.749 Å)