6WS6

Structural and functional analysis of a potent sarbecovirus neutralizing antibody

Summary for 6WS6

• Entry DOI: 10.2210/pdb6ws6/pdb
• Descriptor: S309 antigen-binding (Fab) fragment, heavy chain, S309 antigen-binding (Fab) fragment, light chain, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) (3 entities in total)
• Functional Keywords: fusion protein, neutralizing antibody, sarbecovirus, structural genomics, seattle structural genomics center for infectious disease, ssgcid, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 143932.33

Authors

Pinto, D.,Park, Y.J.,Beltramello, M.,Walls, A.C.,Tortorici, M.A.,Bianchi, S.,Jaconi, S.,Culap, K.,Zatta, F.,Marco, A.D.,Peter, A.,Guarino, B.,Spreafico, R.,Cameroni, E.,Case, J.B.,Chen, R.E.,Havenar-Daughton, C.,Snell, G.,Telenti, A.,Virgin, H.W.,Lanzavecchia, A.,Diamond, M.S.,Fink, K.,Veesler, D.,Corti, D.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-04-30, release date: 2020-05-27, Last modification date: 2023-10-18)

• Primary citation: Pinto, D.,Park, Y.J.,Beltramello, M.,Walls, A.C.,Tortorici, M.A.,Bianchi, S.,Jaconi, S.,Culap, K.,Zatta, F.,De Marco, A.,Peter, A.,Guarino, B.,Spreafico, R.,Cameroni, E.,Case, J.B.,Chen, R.E.,Havenar-Daughton, C.,Snell, G.,Telenti, A.,Virgin, H.W.,Lanzavecchia, A.,Diamond, M.S.,Fink, K.,Veesler, D.,Corti, D.; Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.; Nature, 583:290-295, 2020; PubMed: 32422645; DOI: 10.1038/s41586-020-2349-y

Experimental method

X-RAY DIFFRACTION (3.3 Å)