6WS4
Crystal structure of KRAS-G12D/K104Q mutant, GDP-bound
Summary for 6WS4
Entry DOI | 10.2210/pdb6ws4/pdb |
Related | 6WS2 |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | kras, ras, mg, k-ras, small gtpase, guanine nucleotide, oncoprotein, gmppnp, gppnhp, k104, g12d, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 79663.39 |
Authors | Tran, T.H.,Simanshu, D.K. (deposition date: 2020-04-30, release date: 2021-11-10, Last modification date: 2023-10-18) |
Primary citation | Yang, M.H.,Tran, T.H.,Hunt, B.,Agnor, R.,Johnson, C.W.,Shui, B.,Waybright, T.J.,Nowak, J.A.,Stephen, A.G.,Simanshu, D.K.,Haigis, K.M. Allosteric regulation of switch-II domain controls KRAS oncogenicity. Cancer Res., 2023 Cited by PubMed: 37556505DOI: 10.1158/0008-5472.CAN-22-3210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
Download full validation report