6WPS

Structure of the SARS-CoV-2 spike glycoprotein in complex with the S309 neutralizing antibody Fab fragment

Summary for 6WPS

• Entry DOI: 10.2210/pdb6wps/pdb
• EMDB information: 21864 21865
• Descriptor: spike glycoprotein, S309 neutralizing antibody heavy chain, S309 neutralizing antibody light chain, ... (6 entities in total)
• Functional Keywords: sars-cov-2, sars-cov, spike glycoprotein, fusion protein, neutralizing antibody, sarbecovirus, structural genomics, seattle structural genomics center for infectious disease, ssgcid, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 9
• Total formula weight: 516512.57

Authors

Pinto, D.,Park, Y.J.,Beltramello, M.,Walls, A.C.,Tortorici, M.A.,Bianchi, S.,Jaconi, S.,Culap, K.,Zatta, F.,De Marco, A.,Peter, A.,Guarino, B.,Spreafico, R.,Cameroni, E.,Case, J.B.,Chen, R.E.,Havenar-Daughton, C.,Snell, G.,Virgin, H.W.,Lanzavecchia, A.,Diamond, M.S.,Fink, K.,Veesler, D.,Corti, D.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-04-27, release date: 2020-05-27, Last modification date: 2021-05-19)

• Primary citation: Pinto, D.,Park, Y.J.,Beltramello, M.,Walls, A.C.,Tortorici, M.A.,Bianchi, S.,Jaconi, S.,Culap, K.,Zatta, F.,De Marco, A.,Peter, A.,Guarino, B.,Spreafico, R.,Cameroni, E.,Case, J.B.,Chen, R.E.,Havenar-Daughton, C.,Snell, G.,Telenti, A.,Virgin, H.W.,Lanzavecchia, A.,Diamond, M.S.,Fink, K.,Veesler, D.,Corti, D.; Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.; Nature, 583:290-295, 2020; PubMed: 32422645; DOI: 10.1038/s41586-020-2349-y

Experimental method

ELECTRON MICROSCOPY (3.1 Å)