6WOQ
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody HC1AM and non neutralizing antibody E1
Summary for 6WOQ
Entry DOI | 10.2210/pdb6woq/pdb |
Descriptor | Fab E1 heavy chain, Fab E1 light chain, Envelope glycoprotein E2, ... (7 entities in total) |
Functional Keywords | hcv, broadly neutralizing antibodies, bnabs, e2 core, ighv1-69, immune system, immune system-viral protein complex, immune system/viral protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 10 |
Total formula weight | 236536.06 |
Authors | Tzarum, N.,Wilson, I.A.,Law, M. (deposition date: 2020-04-25, release date: 2020-08-19, Last modification date: 2023-10-18) |
Primary citation | Tzarum, N.,Giang, E.,Kadam, R.U.,Chen, F.,Nagy, K.,Augestad, E.H.,Velazquez-Moctezuma, R.,Keck, Z.Y.,Hua, Y.,Stanfield, R.L.,Dreux, M.,Prentoe, J.,Foung, S.K.H.,Bukh, J.,Wilson, I.A.,Law, M. An alternate conformation of HCV E2 neutralizing face as an additional vaccine target. Sci Adv, 6:eabb5642-eabb5642, 2020 Cited by PubMed: 32754640DOI: 10.1126/sciadv.abb5642 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.667 Å) |
Structure validation
Download full validation report