6WOQ

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody HC1AM and non neutralizing antibody E1

Summary for 6WOQ

• Entry DOI: 10.2210/pdb6woq/pdb
• Descriptor: Fab E1 heavy chain, Fab E1 light chain, Envelope glycoprotein E2, ... (7 entities in total)
• Functional Keywords: hcv, broadly neutralizing antibodies, bnabs, e2 core, ighv1-69, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 236536.06

Authors

Tzarum, N.,Wilson, I.A.,Law, M. (deposition date: 2020-04-25, release date: 2020-08-19, Last modification date: 2023-10-18)

• Primary citation: Tzarum, N.,Giang, E.,Kadam, R.U.,Chen, F.,Nagy, K.,Augestad, E.H.,Velazquez-Moctezuma, R.,Keck, Z.Y.,Hua, Y.,Stanfield, R.L.,Dreux, M.,Prentoe, J.,Foung, S.K.H.,Bukh, J.,Wilson, I.A.,Law, M.; An alternate conformation of HCV E2 neutralizing face as an additional vaccine target.; Sci Adv, 6:eabb5642-eabb5642, 2020; PubMed: 32754640; DOI: 10.1126/sciadv.abb5642

Experimental method

X-RAY DIFFRACTION (3.667 Å)