6WOI
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1-Diphosphoinositol pentakisphosphate, Mg, and Fluoride ion, presoaked with 1,5-IP8, Mg and Fluoride for 30 seconds
Summary for 6WOI
Entry DOI | 10.2210/pdb6woi/pdb |
Descriptor | Diphosphoinositol polyphosphate phosphohydrolase 1, (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | phosphatase, nudix, catalysis mechanism, substrate specificity, inositol, inositol pyrophosphate, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20445.76 |
Authors | Zong, G.N.,Wang, H.C.,Shears, S.B. (deposition date: 2020-04-24, release date: 2021-03-03, Last modification date: 2024-03-06) |
Primary citation | Zong, G.,Jork, N.,Hostachy, S.,Fiedler, D.,Jessen, H.J.,Shears, S.B.,Wang, H. New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. Faseb J., 35:e21275-e21275, 2021 Cited by PubMed: 33475202DOI: 10.1096/fj.202001489R PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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