6WOH

Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1,5-di-methylenebisphosphonate inositol tetrakisphosphate (1,5-PCP-IP4)

Summary for 6WOH

Entry DOI	10.2210/pdb6woh/pdb
Descriptor	Diphosphoinositol polyphosphate phosphohydrolase 1, {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl]bis[oxy(hydroxyphosphoryl)methanediyl]}bis(phosphonic acid), SULFATE ION, ... (4 entities in total)
Functional Keywords	phosphatase, nudix, catalysis mechanism, substrate specificity, inositol, inositol pyrophosphate, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	20551.10
Authors	Zong, G.N.,Wang, H.C.,Shears, S.B. (deposition date: 2020-04-24, release date: 2021-03-03, Last modification date: 2024-03-06)
Primary citation	Zong, G.,Jork, N.,Hostachy, S.,Fiedler, D.,Jessen, H.J.,Shears, S.B.,Wang, H. New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. Faseb J., 35:e21275-e21275, 2021 Cited by PubMed: 33475202 DOI: 10.1096/fj.202001489R PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation