6WOH

Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1,5-di-methylenebisphosphonate inositol tetrakisphosphate (1,5-PCP-IP4)

6WOH の概要

• エントリーDOI: 10.2210/pdb6woh/pdb
• 分子名称: Diphosphoinositol polyphosphate phosphohydrolase 1, {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl]bis[oxy(hydroxyphosphoryl)methanediyl]}bis(phosphonic acid), SULFATE ION, ... (4 entities in total)
• 機能のキーワード: phosphatase, nudix, catalysis mechanism, substrate specificity, inositol, inositol pyrophosphate, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20551.10

構造登録者

Zong, G.N.,Wang, H.C.,Shears, S.B. (登録日: 2020-04-24, 公開日: 2021-03-03, 最終更新日: 2024-03-06)

• 主引用文献: Zong, G.,Jork, N.,Hostachy, S.,Fiedler, D.,Jessen, H.J.,Shears, S.B.,Wang, H.; New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1.; Faseb J., 35:e21275-e21275, 2021; PubMed: 33475202; DOI: 10.1096/fj.202001489R

実験手法

X-RAY DIFFRACTION (1.7 Å)