6WMW

GFRAL receptor bound with two antibody Fabs (3P10, 25M22)

Summary for 6WMW

• Entry DOI: 10.2210/pdb6wmw/pdb
• Descriptor: GDNF family receptor alpha-like, FAB3P10 heavy chain fragment, FAB3P10 light chain, ... (5 entities in total)
• Functional Keywords: receptor, signaling, antibodes, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 127057.10

Authors

White, A.,Lakshminarasimhan, D.,Olland, A.,Suto, R.K. (deposition date: 2020-04-21, release date: 2020-07-15, Last modification date: 2023-10-18)

• Primary citation: Suriben, R.,Chen, M.,Higbee, J.,Oeffinger, J.,Ventura, R.,Li, B.,Mondal, K.,Gao, Z.,Ayupova, D.,Taskar, P.,Li, D.,Starck, S.R.,Chen, H.H.,McEntee, M.,Katewa, S.D.,Phung, V.,Wang, M.,Kekatpure, A.,Lakshminarasimhan, D.,White, A.,Olland, A.,Haldankar, R.,Solloway, M.J.,Hsu, J.Y.,Wang, Y.,Tang, J.,Lindhout, D.A.,Allan, B.B.; Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.; Nat Med, 26:1264-1270, 2020; PubMed: 32661391; DOI: 10.1038/s41591-020-0945-x

Experimental method

X-RAY DIFFRACTION (2.91 Å)