6WKJ

Crystal structure of pentalenene synthase mutant F76H complexed with 12,13-difluorofarnesyl diphosphate

6WKJ の概要

• エントリーDOI: 10.2210/pdb6wkj/pdb
• 分子名称: Pentalenene synthase, (2E,6E)-12-fluoro-11-(fluoromethyl)-3,7-dimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate (3 entities in total)
• 機能のキーワード: terpene synthase, terpene synthase fold, sesquiterpene, fluoro analog, metal binding, metal binding protein, lyase-inhibitor complex, lyase/inhibitor
• 由来する生物種: Streptomyces sp.
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76501.08

構造登録者

Prem Kumar, R.,Matos, J.O.,Oprian, D.D. (登録日: 2020-04-16, 公開日: 2020-08-26, 最終更新日: 2023-10-18)

• 主引用文献: Matos, J.O.,Kumar, R.P.,Ma, A.C.,Patterson, M.,Krauss, I.J.,Oprian, D.D.; Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase.; Biochemistry, 59:3271-3283, 2020; PubMed: 32786410; DOI: 10.1021/acs.biochem.0c00518

実験手法

X-RAY DIFFRACTION (2.3 Å)