6WKF

Crystal structure of pentalenene synthase mutant F76Y complexed with 12,13-difluorofarnesyl diphosphate

Summary for 6WKF

• Entry DOI: 10.2210/pdb6wkf/pdb
• Descriptor: Pentalenene synthase, (2E,6E)-12-fluoro-11-(fluoromethyl)-3,7-dimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate (3 entities in total)
• Functional Keywords: terpene synthase, terpene synthase fold, sesquiterpene, fluoro analog, metal binding, metal binding protein, lyase-inhibitor complex, lyase/inhibitor
• Biological source: Streptomyces sp.
• Total number of polymer chains: 2
• Total formula weight: 76551.13

Authors

Prem Kumar, R.,Matos, J.O.,Oprian, D.D. (deposition date: 2020-04-16, release date: 2020-08-26, Last modification date: 2023-10-18)

• Primary citation: Matos, J.O.,Kumar, R.P.,Ma, A.C.,Patterson, M.,Krauss, I.J.,Oprian, D.D.; Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase.; Biochemistry, 59:3271-3283, 2020; PubMed: 32786410; DOI: 10.1021/acs.biochem.0c00518

Experimental method

X-RAY DIFFRACTION (2.5 Å)