6WKA

human carbonic anhydrase II bound to an inhibitor modified with azidothymidine

Summary for 6WKA

Entry DOI	10.2210/pdb6wka/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 3'-deoxy-3'-(4-{[(4-sulfamoylphenyl)amino]methyl}-1H-1,2,3-triazol-1-yl)thymidine, ... (4 entities in total)
Functional Keywords	human ca ii, inhibitor, click chemistry, azidothymidine, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29831.97
Authors	Peat, T.S. (deposition date: 2020-04-15, release date: 2021-02-24, Last modification date: 2023-10-18)
Primary citation	Berrino, E.,Angeli, A.,Zhdanov, D.D.,Kiryukhina, A.P.,Milaneschi, A.,De Luca, A.,Bozdag, M.,Carradori, S.,Selleri, S.,Bartolucci, G.,Peat, T.S.,Ferraroni, M.,Supuran, C.T.,Carta, F. Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors. J.Med.Chem., 63:7392-7409, 2020 Cited by PubMed: 32463228 DOI: 10.1021/acs.jmedchem.0c00636 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.34 Å)

Structure validation