6WJF

PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma

6WJF の概要

• エントリーDOI: 10.2210/pdb6wjf/pdb
• EMDBエントリー: 21692
• 分子名称: DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit (2 entities in total)
• 機能のキーワード: fibrolamellar hepatoceullar carcinoma, pka, camp, kinase, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 187031.67

構造登録者

Lu, T.-W.,Aoto, P.C.,Weng, J.-H.,Nielsen, C.,Cash, J.N.,Hall, J.,Zhang, P.,Simon, S.M.,Cianfrocco, M.A.,Taylor, S.S. (登録日: 2020-04-13, 公開日: 2020-12-02, 最終更新日: 2024-03-06)

• 主引用文献: Lu, T.W.,Aoto, P.C.,Weng, J.H.,Nielsen, C.,Cash, J.N.,Hall, J.,Zhang, P.,Simon, S.M.,Cianfrocco, M.A.,Taylor, S.S.; Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.; Plos Biol., 18:e3001018-e3001018, 2020; PubMed: 33370777; DOI: 10.1371/journal.pbio.3001018

実験手法

ELECTRON MICROSCOPY (7.5 Å)