6WHZ

Histone deacetylases complex with peptide macrocycles

Summary for 6WHZ

• Entry DOI: 10.2210/pdb6whz/pdb
• Descriptor: Histone deacetylase 2, U2M-ASN-HYP-LYS-GLN-DLY-TRP-GLY peptide macrocycle, ZINC ION, ... (7 entities in total)
• Functional Keywords: anchor extension, de novo design macrocycles, histone deacetylases, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 135899.57

Authors

Bera, A.K.,Hosseinzadeh, P.,Watson, P.,Baker, D. (deposition date: 2020-04-08, release date: 2021-04-21, Last modification date: 2023-11-15)

• Primary citation: Hosseinzadeh, P.,Watson, P.R.,Craven, T.W.,Li, X.,Rettie, S.,Pardo-Avila, F.,Bera, A.K.,Mulligan, V.K.,Lu, P.,Ford, A.S.,Weitzner, B.D.,Stewart, L.J.,Moyer, A.P.,Di Piazza, M.,Whalen, J.G.,Greisen, P.J.,Christianson, D.W.,Baker, D.; Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.; Nat Commun, 12:3384-3384, 2021; PubMed: 34099674; DOI: 10.1038/s41467-021-23609-8

Experimental method

X-RAY DIFFRACTION (2.9 Å)