6WHA

HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)

Summary for 6WHA

• Entry DOI: 10.2210/pdb6wha/pdb
• EMDB information: 21669
• Descriptor: Soluble cytochrome b562,5-hydroxytryptamine receptor 2A chimera, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: 5ht2a, g protein, 25-cn-nboh, gpcr, cryo-em, membrane protein-immune system complex, membrane protein/immune system
• Biological source: Escherichia coli; More
• Total number of polymer chains: 5
• Total formula weight: 160512.66

Authors

Skiniotis, G.,Roth, B.,Kim, K.,Panova, O. (deposition date: 2020-04-07, release date: 2020-09-23)

• Primary citation: Kim, K.,Che, T.,Panova, O.,Shoichet, B.K.,Skiniotis, G.,Roth, B.L.; Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor; Cell(Cambridge,Mass.), 182:1574-1588, 2020; DOI: 10.1016/j.cell.2020.08.024

Experimental method

ELECTRON MICROSCOPY (3.36 Å)