6WHA
HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Soluble cytochrome b562,5-hydroxytryptamine receptor 2A chimera | polymer | 497 | 56167.3 | 1 | UniProt (P0ABE7) UniProt (P28223) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,5-HT-2A,Serotonin receptor 2A |
2 | B | G subunit q (Gi2-mini-Gq chimeric) | polymer | 246 | 28084.8 | 1 | Homo sapiens (Human) | ||
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
4 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
5 | E | single Fab chain (svFv16) | polymer | 267 | 28668.9 | 1 | Homo sapiens (Human) | ||
6 | A | 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile | non-polymer | 312.4 | 1 | Chemie (U0G) |
Sequence modifications
A: -42 - 62 (UniProt: P0ABE7)
A: 66 - 404 (UniProt: P28223)
C: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Met -92 | - | expression tag |
Lys -91 | - | expression tag |
Thr -90 | - | expression tag |
Ile -89 | - | expression tag |
Ile -88 | - | expression tag |
Ala -87 | - | expression tag |
Leu -86 | - | expression tag |
Ser -85 | - | expression tag |
Tyr -84 | - | expression tag |
Ile -83 | - | expression tag |
Phe -82 | - | expression tag |
Cys -81 | - | expression tag |
Leu -80 | - | expression tag |
Val -79 | - | expression tag |
Phe -78 | - | expression tag |
Ala -77 | - | expression tag |
Asp -76 | - | expression tag |
Tyr -75 | - | expression tag |
Lys -74 | - | expression tag |
Asp -73 | - | expression tag |
Asp -72 | - | expression tag |
Asp -71 | - | expression tag |
Asp -70 | - | expression tag |
Ala -69 | - | expression tag |
Lys -68 | - | expression tag |
Leu -67 | - | expression tag |
Gln -66 | - | expression tag |
Thr -65 | - | expression tag |
Met -64 | - | expression tag |
His -63 | - | expression tag |
His -62 | - | expression tag |
His -61 | - | expression tag |
His -60 | - | expression tag |
His -59 | - | expression tag |
His -58 | - | expression tag |
His -57 | - | expression tag |
His -56 | - | expression tag |
His -55 | - | expression tag |
His -54 | - | expression tag |
Glu -53 | - | expression tag |
Asn -52 | - | expression tag |
Leu -51 | - | expression tag |
Tyr -50 | - | expression tag |
Phe -49 | - | expression tag |
Gln -48 | - | expression tag |
Gly -47 | - | expression tag |
Gly -46 | - | expression tag |
Thr -45 | - | expression tag |
Thr -44 | - | expression tag |
Met -43 | - | expression tag |
Trp -36 | Met 29 | conflict |
Ile 59 | His 124 | conflict |
Leu 63 | - | linker |
Gly 64 | - | linker |
Ser 65 | - | linker |
C: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Met -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 160200.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 312.4 | |
All* | Total formula weight | 160512.7 |