6WDV

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Dimethylaminomethylindole Phenylhydroxamate Inhibitor

Summary for 6WDV

Entry DOI	10.2210/pdb6wdv/pdb
Descriptor	Polyamine deacetylase HDAC10, 4-({3-[(dimethylamino)methyl]-1H-indol-1-yl}methyl)-N-hydroxybenzamide, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	histone deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	75712.58
Authors	Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2020-04-01, release date: 2020-07-22, Last modification date: 2023-10-18)
Primary citation	Herbst-Gervasoni, C.J.,Steimbach, R.R.,Morgen, M.,Miller, A.K.,Christianson, D.W. Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. Acs Chem.Biol., 15:2154-2163, 2020 Cited by PubMed: 32659072 DOI: 10.1021/acschembio.0c00362 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation