6WBW
Structure of Human HDAC2 in complex with an ethyl ketone inhibitor
Summary for 6WBW
Entry DOI | 10.2210/pdb6wbw/pdb |
Descriptor | Histone deacetylase 2, N-{(1S)-7,7-dihydroxy-1-[5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl]nonyl}-1-methylazetidine-3-carboxamide, ZINC ION, ... (6 entities in total) |
Functional Keywords | histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 131746.22 |
Authors | Klein, D.J.,Yu, W. (deposition date: 2020-03-27, release date: 2020-05-06, Last modification date: 2024-03-06) |
Primary citation | Yu, W.,Liu, J.,Yu, Y.,Zhang, V.,Clausen, D.,Kelly, J.,Wolkenberg, S.,Beshore, D.,Duffy, J.L.,Chung, C.C.,Myers, R.W.,Klein, D.J.,Fells, J.,Holloway, K.,Wu, J.,Wu, G.,Howell, B.J.,Barnard, R.J.O.,Kozlowski, J. Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation. Bioorg.Med.Chem.Lett., 30:127197-127197, 2020 Cited by PubMed: 32331932DOI: 10.1016/j.bmcl.2020.127197 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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