6WAK

A crystal structure of EGFR(T790M/V948R) in complex with LN3754

Summary for 6WAK

Entry DOI	10.2210/pdb6wak/pdb
Descriptor	Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	cancer, transferase, inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	152097.65
Authors	Heppner, D.E.,Eck, M.J. (deposition date: 2020-03-25, release date: 2021-03-31, Last modification date: 2023-10-18)
Primary citation	Wittlinger, F.,Heppner, D.E.,To, C.,Gunther, M.,Shin, B.H.,Rana, J.K.,Schmoker, A.M.,Beyett, T.S.,Berger, L.M.,Berger, B.T.,Bauer, N.,Vasta, J.D.,Corona, C.R.,Robers, M.B.,Knapp, S.,Janne, P.A.,Eck, M.J.,Laufer, S.A. Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J.Med.Chem., 65:1370-1383, 2022 Cited by PubMed: 34668706 DOI: 10.1021/acs.jmedchem.1c00848 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation