6WA2

Crystal structure of EGFR(T790M/V948R) in complex with LN3753

Summary for 6WA2

Entry DOI	10.2210/pdb6wa2/pdb
Descriptor	Epidermal growth factor receptor, N-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1H-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	drug discovery, cancer, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	151933.87
Authors	Heppner, D.E.,Eck, M.J. (deposition date: 2020-03-24, release date: 2021-03-31, Last modification date: 2023-10-18)
Primary citation	Wittlinger, F.,Heppner, D.E.,To, C.,Gunther, M.,Shin, B.H.,Rana, J.K.,Schmoker, A.M.,Beyett, T.S.,Berger, L.M.,Berger, B.T.,Bauer, N.,Vasta, J.D.,Corona, C.R.,Robers, M.B.,Knapp, S.,Janne, P.A.,Eck, M.J.,Laufer, S.A. Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J.Med.Chem., 65:1370-1383, 2022 Cited by PubMed: 34668706 DOI: 10.1021/acs.jmedchem.1c00848 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation