6WA0

De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release

Summary for 6WA0

• Entry DOI: 10.2210/pdb6wa0/pdb
• Descriptor: De novo designed receptor transmembrane domain proMP C3.1 (1 entity in total)
• Functional Keywords: transmembrane domain, de novo design, biosynthetic protein
• Biological source: synthetic construct
• Total number of polymer chains: 9
• Total formula weight: 31276.92

Authors

Call, M.J.,Call, M.E.,Chandler, N.J.,Nguyen, J.V.,Trenker, R. (deposition date: 2020-03-24, release date: 2021-03-31, Last modification date: 2023-10-18)

• Primary citation: Elazar, A.,Chandler, N.J.,Davey, A.S.,Weinstein, J.Y.,Nguyen, J.V.,Trenker, R.,Jenkins, M.,Call, M.J.,Call, M.E.,Fleishman, S.J.; De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.484 Å)