6W9L

Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with deacetylated deflazacort and PGC1a coregulator fragment

6W9L の概要

• エントリーDOI: 10.2210/pdb6w9l/pdb
• 分子名称: Glucocorticoid Receptor, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8-trimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-2-one, ... (5 entities in total)
• 機能のキーワード: glucocorticoid receptor, anti-inflammation drug, hormone
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30535.74

構造登録者

Liu, X.,Ortlund, E.A. (登録日: 2020-03-23, 公開日: 2020-11-04, 最終更新日: 2023-10-18)

• 主引用文献: Liu, X.,Wang, Y.,Gutierrez, J.S.,Damsker, J.M.,Nagaraju, K.,Hoffman, E.P.,Ortlund, E.A.; Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment.; Proc.Natl.Acad.Sci.USA, 117:24285-24293, 2020; PubMed: 32917814; DOI: 10.1073/pnas.2006890117

実験手法

X-RAY DIFFRACTION (1.45 Å)