6W8D
Structure of DNMT3A (R882H) in complex with CGT DNA
Summary for 6W8D
Entry DOI | 10.2210/pdb6w8d/pdb |
Descriptor | DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, CGT DNA (25-MER), ... (5 entities in total) |
Functional Keywords | dna methylation, dnmt3a(r882h), aml, epigenetics, transferase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 129887.51 |
Authors | Anteneh, H.,Song, J. (deposition date: 2020-03-20, release date: 2020-04-15, Last modification date: 2023-10-18) |
Primary citation | Anteneh, H.,Fang, J.,Song, J. Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11:2294-2294, 2020 Cited by PubMed: 32385248DOI: 10.1038/s41467-020-16213-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.598 Å) |
Structure validation
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