6W7F
Structure of EED bound to inhibitor 5285
Summary for 6W7F
Entry DOI | 10.2210/pdb6w7f/pdb |
Descriptor | Polycomb protein EED, 8-(6-cyclopropylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine, GLYCEROL, ... (4 entities in total) |
Functional Keywords | inhibitor, gene regulation, transcription-inhibitor complex |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43463.33 |
Authors | Petrunak, E.M.,Stuckey, J.A. (deposition date: 2020-03-19, release date: 2020-07-08, Last modification date: 2023-10-18) |
Primary citation | Rej, R.K.,Wang, C.,Lu, J.,Wang, M.,Petrunak, E.,Zawacki, K.P.,McEachern, D.,Fernandez-Salas, E.,Yang, C.Y.,Wang, L.,Li, R.,Chinnaswamy, K.,Wen, B.,Sun, D.,Stuckey, J.,Zhou, Y.,Chen, J.,Tang, G.,Wang, S. EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. J.Med.Chem., 63:7252-7267, 2020 Cited by PubMed: 32580550DOI: 10.1021/acs.jmedchem.0c00479 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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