6W7A

The crystal structure of the 2009/H1N1/California PA endonuclease mutant E119D bound to DNA oligomer TAGCAT (uncleaved, 5mM overnight DNA soak)

Summary for 6W7A

• Entry DOI: 10.2210/pdb6w7a/pdb
• Related: 6W5P
• Descriptor: Protein PA-X,Polymerase acidic protein, DNA (5'-D(P*TP*AP*GP*CP*AP*T)-3'), GLYCEROL, ... (6 entities in total)
• Functional Keywords: nuclease, influenza, dna oligomer, uncleaved, viral protein, viral protein-dna complex, viral protein/dna
• Biological source: Influenza A virus; More
• Total number of polymer chains: 2
• Total formula weight: 25886.12

Authors

Cuypers, M.G.,Kumar, G.,Webb, T.,White, S.W. (deposition date: 2020-03-18, release date: 2021-02-03, Last modification date: 2023-10-25)

• Primary citation: Kumar, G.,Cuypers, M.,Webby, R.R.,Webb, T.R.,White, S.W.; Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.; Nucleic Acids Res., 49:1609-1618, 2021; PubMed: 33469660; DOI: 10.1093/nar/gkaa1294

Experimental method

X-RAY DIFFRACTION (2.09 Å)