6W74
Structure of cIAP with compound 15
Summary for 6W74
Entry DOI | 10.2210/pdb6w74/pdb |
Descriptor | Baculoviral IAP repeat-containing protein 2, ZINC ION, 14-{[(3S)-2-(N-methyl-L-alanyl-3-methyl-L-valyl)-3-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}-3,6,9,12-tetraoxatetradecan-1-yl (3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate, ... (4 entities in total) |
Functional Keywords | ciap e3 protac, ligase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 12564.48 |
Authors | Calabrese, M.F.,Schiemer, J.S. (deposition date: 2020-03-18, release date: 2020-11-18, Last modification date: 2023-10-18) |
Primary citation | Calabrese, M.F.,Schiemer, J.S.,Horst, R.,Meng, Y.,Montgomery, J.,Xu, Y.,Feng, X.,Borzilleri, K.,Uccello, D.P.,Leverett, C.,Brown, S.,Che, Y.,Brown, M.F.,Hayward, M.M.,Gilbert, A.M.,Noe, M.C. Structural Characterization of BTK:PROTAC:cIAP Ternary Complexes: From Snapshots to Ensembles Nat.Chem.Biol., 2020 |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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