6W6D
Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with SGC6870 inhibitor
Summary for 6W6D
Entry DOI | 10.2210/pdb6w6d/pdb |
Descriptor | Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, (5R)-4-(5-bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one, ... (4 entities in total) |
Functional Keywords | prmt6 and sgc6870 inhibitor, structural genomics, structural genomics consortium, sgc, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42928.36 |
Authors | Halabelian, L.,Zeng, H.,Dong, A.,Jin, J.,Shen, Y.,Kaniskan, H.U.,Hutchinson, A.,Seitova, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2020-03-16, release date: 2020-04-29, Last modification date: 2023-10-18) |
Primary citation | Shen, Y.,Li, F.,Szewczyk, M.M.,Halabelian, L.,Chau, I.,Eram, M.S.,Dela Sena, C.,Park, K.S.,Meng, F.,Chen, H.,Zeng, H.,Dong, A.,Wu, H.,Trush, V.V.,McLeod, D.,Zepeda-Velazquez, C.A.,Campbell, R.M.,Mader, M.M.,Watson, B.M.,Schapira, M.,Arrowsmith, C.H.,Al-Awar, R.,Barsyte-Lovejoy, D.,Kaniskan, H.U.,Brown, P.J.,Vedadi, M.,Jin, J. A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J.Med.Chem., 64:3697-3706, 2021 Cited by PubMed: 33591753DOI: 10.1021/acs.jmedchem.0c02160 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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