6W5A

Crystal Structure of the Fab fragment of humanized 5c8 antibody containing the fluorescent non-canonical amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine at pH 9.7

6W5A の概要

• エントリーDOI: 10.2210/pdb6w5a/pdb
• 関連するPDBエントリー: 6bjz 6w4w
• 分子名称: Antibody 5c8* Fab Heavy Chain, Antibody 5c8* Fab Light Chain (3 entities in total)
• 機能のキーワード: immunoglobulin, fab, l-(7-hydroxycoumarin-4-yl)ethylglycine, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48075.43

構造登録者

Henderson, J.N.,Simmons, C.R.,Mills, J.H. (登録日: 2020-03-12, 公開日: 2020-12-23, 最終更新日: 2023-11-15)

• 主引用文献: Henderson, J.N.,Simmons, C.R.,Fahmi, N.E.,Jeffs, J.W.,Borges, C.R.,Mills, J.H.; Structural Insights into How Protein Environments Tune the Spectroscopic Properties of a Noncanonical Amino Acid Fluorophore.; Biochemistry, 59:3401-3410, 2020; PubMed: 32845612; DOI: 10.1021/acs.biochem.0c00474

実験手法

X-RAY DIFFRACTION (1.75 Å)