6W4V
Structure of anti-ferroportin Fab45D8
Summary for 6W4V
Entry DOI | 10.2210/pdb6w4v/pdb |
Related | 6W4S |
EMDB information | 21539 |
Descriptor | Fab45D8 Light Chain, Fab45D8 Heavy Chain, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | ferroportin, transporter, iron, hepcidin, antibody, fab, immune system |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 48725.06 |
Authors | Billesboelle, C.B.,Azumaya, C.M.,Gonen, S.,Powers, A.,Kretsch, R.C.,Schneider, S.,Arvedson, T.,Dror, R.O.,Cheng, Y.,Manglik, A. (deposition date: 2020-03-11, release date: 2020-09-09, Last modification date: 2023-10-18) |
Primary citation | Billesbolle, C.B.,Azumaya, C.M.,Kretsch, R.C.,Powers, A.S.,Gonen, S.,Schneider, S.,Arvedson, T.,Dror, R.O.,Cheng, Y.,Manglik, A. Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature, 586:807-811, 2020 Cited by PubMed: 32814342DOI: 10.1038/s41586-020-2668-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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