6W4K

Crystal structure of Lysine Specific Demethylase 1 (LSD1) with CC-90011

6W4K の概要

• エントリーDOI: 10.2210/pdb6w4k/pdb
• 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, 4-[2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile, ... (5 entities in total)
• 機能のキーワード: human lsd1 inhibitor-complex, flavoprotein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89774.17

構造登録者

Hosfield, D.J. (登録日: 2020-03-11, 公開日: 2020-10-21, 最終更新日: 2023-10-18)

• 主引用文献: Kanouni, T.,Severin, C.,Cho, R.W.,Yuen, N.Y.,Xu, J.,Shi, L.,Lai, C.,Del Rosario, J.R.,Stansfield, R.K.,Lawton, L.N.,Hosfield, D.,O'Connell, S.,Kreilein, M.M.,Tavares-Greco, P.,Nie, Z.,Kaldor, S.W.,Veal, J.M.,Stafford, J.A.,Chen, Y.K.; Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).; J.Med.Chem., 63:14522-14529, 2020; PubMed: 33034194; DOI: 10.1021/acs.jmedchem.0c00978

実験手法

X-RAY DIFFRACTION (2.93 Å)