6W4I

APE1 Y269A product complex with abasic DNA

6W4I の概要

• エントリーDOI: 10.2210/pdb6w4i/pdb
• 分子名称: DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(P*(3DR)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (6 entities in total)
• 機能のキーワード: dna repair, ap-endonuclease, dna binding, dna binding protein, lyase-dna complex, lyase/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 87711.14

構造登録者

Freudenthal, B.D.,Hoitsma, N.M. (登録日: 2020-03-10, 公開日: 2020-06-17, 最終更新日: 2023-10-18)

• 主引用文献: Hoitsma, N.M.,Whitaker, A.M.,Beckwitt, E.C.,Jang, S.,Agarwal, P.K.,Van Houten, B.,Freudenthal, B.D.; AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop.; Nucleic Acids Res., 48:7345-7355, 2020; PubMed: 32542366; DOI: 10.1093/nar/gkaa496

実験手法

X-RAY DIFFRACTION (2.2 Å)