6W3B

Structure of apo unphosphorylated IRE1

Summary for 6W3B

Entry DOI	10.2210/pdb6w3b/pdb
Descriptor	Serine/threonine-protein kinase/endoribonuclease IRE1 (2 entities in total)
Functional Keywords	kinase, upr, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	49561.50
Authors	Wallweber, H.,Mortara, K.,Ferri, E.,Rudolph, J.,Wang, W. (deposition date: 2020-03-09, release date: 2020-12-09, Last modification date: 2023-10-18)
Primary citation	Ferri, E.,Le Thomas, A.,Wallweber, H.A.,Day, E.S.,Walters, B.T.,Kaufman, S.E.,Braun, M.G.,Clark, K.R.,Beresini, M.H.,Mortara, K.,Chen, Y.A.,Canter, B.,Phung, W.,Liu, P.S.,Lammens, A.,Ashkenazi, A.,Rudolph, J.,Wang, W. Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands. Nat Commun, 11:6387-6387, 2020 Cited by PubMed: 33318494 DOI: 10.1038/s41467-020-19974-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.57 Å)

Structure validation