6VZ1
Cryo-EM structure of human diacylglycerol O-acyltransferase 1 complexed with acyl-CoA substrate
Summary for 6VZ1
Entry DOI | 10.2210/pdb6vz1/pdb |
EMDB information | 21481 |
Descriptor | Diacylglycerol O-acyltransferase 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) (3 entities in total) |
Functional Keywords | triglyceride biosynthesis, lipid storage, lipid metabolism, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 115614.21 |
Authors | Sui, X.,Wang, K.,Gluchowski, N.,Liao, M.,Walther, C.T.,Farese Jr., V.R. (deposition date: 2020-02-27, release date: 2020-05-13, Last modification date: 2024-03-06) |
Primary citation | Sui, X.,Wang, K.,Gluchowski, N.L.,Elliott, S.D.,Liao, M.,Walther, T.C.,Farese Jr., R.V. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature, 581:323-328, 2020 Cited by PubMed: 32433611DOI: 10.1038/s41586-020-2289-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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