6VY8

NMR solution structure of a triazole bridged trypsin inhibitor based on the framework of SFTI-1

Summary for 6VY8

• Entry DOI: 10.2210/pdb6vy8/pdb
• Related: 6U22 6U24
• NMR Information: BMRB: 30729
• Related PRD ID: PRD_002375
• Descriptor: Trypsin inhibitor GLY-ARG-RVJ-THR-LYS-SER-ILE-PRO-PRO-ILE-2AG-PHE-PRO-ASP (1 entity in total)
• Functional Keywords: triazole, disulfide mimetic, inhibitor, biosynthetic protein
• Biological source: Helianthus annuus (common sunflower)
• Total number of polymer chains: 1
• Total formula weight: 1542.78

Authors

White, A.M.,Harvey, P.J.,Durek, T.,Craik, D.J. (deposition date: 2020-02-25, release date: 2020-07-01, Last modification date: 2023-11-15)

• Primary citation: White, A.M.,de Veer, S.J.,Wu, G.,Harvey, P.J.,Yap, K.,King, G.J.,Swedberg, J.E.,Wang, C.K.,Law, R.H.P.,Durek, T.,Craik, D.J.; Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.; Angew.Chem.Int.Ed.Engl., 2020; PubMed: 32270580; DOI: 10.1002/anie.202003435

Experimental method

SOLUTION NMR