6VXU

Structure of Human Vaccinia-related Kinase 1 (VRK1) bound to ACH471

Summary for 6VXU

• Entry DOI: 10.2210/pdb6vxu/pdb
• Descriptor: Serine/threonine-protein kinase VRK1, (7R)-8-(cyclopropylmethyl)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, SULFATE ION, ... (6 entities in total)
• Functional Keywords: protein kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 167587.05

Authors

dos Reis, C.V.,Dutra, L.A.,Gama, F.H.,Mascarello, A.,Azevedo, H.,Guimaraes, C.R.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Counago, R.M.,Structural Genomics Consortium (SGC) (deposition date: 2020-02-24, release date: 2021-03-03, Last modification date: 2023-10-11)

• Primary citation: Guimaraes, C.R.,Counago, R.M.; Structure of Human Vaccinia-related Kinase 1 (VRK1) bound to ACH471; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)