6VVS
Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with antibiotic Sorangicin
Summary for 6VVS
Entry DOI | 10.2210/pdb6vvs/pdb |
Descriptor | DNA-directed RNA polymerase subunit alpha, SULFATE ION, 1,2-ETHANEDIOL, ... (14 entities in total) |
Functional Keywords | dna binding, antibiotic, transcription, transferase-dna-antibiotic complex, transferase/dna/antibiotic |
Biological source | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) More |
Total number of polymer chains | 11 |
Total formula weight | 487145.74 |
Authors | Lilic, M.,Braffman, N.,Darst, S.A.,Campbell, E.A. (deposition date: 2020-02-18, release date: 2020-10-21, Last modification date: 2023-10-11) |
Primary citation | Lilic, M.,Chen, J.,Boyaci, H.,Braffman, N.,Hubin, E.A.,Herrmann, J.,Muller, R.,Mooney, R.,Landick, R.,Darst, S.A.,Campbell, E.A. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117:30423-30432, 2020 Cited by PubMed: 33199626DOI: 10.1073/pnas.2013706117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.112 Å) |
Structure validation
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