6VTO

Crystal structure of human Galectin-7 in complex with 4-O-beta-D-Galactopyranosyl-D-glucose

Summary for 6VTO

Entry DOI	10.2210/pdb6vto/pdb
Descriptor	Galectin-7, (2~{R},3~{R},4~{R},5~{R})-4-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-2,3,5, 6-tetrakis(oxidanyl)hexanal (3 entities in total)
Functional Keywords	human galectin-7, lactose-furanose, sugar binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	30616.29
Authors	Pham, N.T.H.,Calmettes, C.,Doucet, N. (deposition date: 2020-02-13, release date: 2021-08-25, Last modification date: 2023-10-11)
Primary citation	Pham, N.T.H.,Letourneau, M.,Fortier, M.,Begin, G.,Al-Abdul-Wahid, M.S.,Pucci, F.,Folch, B.,Rooman, M.,Chatenet, D.,St-Pierre, Y.,Lague, P.,Calmettes, C.,Doucet, N. Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7. J.Biol.Chem., 297:101308-101308, 2021 Cited by PubMed: 34673030 DOI: 10.1016/j.jbc.2021.101308 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation