6VSW

Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORgt

6VSW の概要

• エントリーDOI: 10.2210/pdb6vsw/pdb
• 分子名称: RAR-related orphan receptor C, 5-(2,3-dichloro-4-{[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl}phenyl)-4-(4-fluoropiperidine-1-carbonyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide (2 entities in total)
• 機能のキーワード: nuclear receptor rorgt, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55451.63

構造登録者

Spurlino, J.,Milligan, C. (登録日: 2020-02-12, 公開日: 2020-05-13, 最終更新日: 2023-10-11)

• 主引用文献: Gege, C.,Albers, M.,Kinzel, O.,Kleymann, G.,Schluter, T.,Steeneck, C.,Hoffmann, T.,Xue, X.,Cummings, M.D.,Spurlino, J.,Milligan, C.,Fourie, A.M.,Edwards, J.P.,Leonard, K.,Coe, K.,Scott, B.,Pippel, D.,Goldberg, S.D.; Optimization and biological evaluation of thiazole-bis-amide inverse agonists of ROR gamma t.; Bioorg.Med.Chem.Lett., 30:127205-127205, 2020; PubMed: 32336498; DOI: 10.1016/j.bmcl.2020.127205

実験手法

X-RAY DIFFRACTION (3.202 Å)