6VSK
Crystal structure of the P-Rex1 DEP1 domain
Summary for 6VSK
Entry DOI | 10.2210/pdb6vsk/pdb |
Descriptor | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (2 entities in total) |
Functional Keywords | dep domain, p-rex1, metastasis, domain-swapped, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 10969.66 |
Authors | Tesmer, J.,Ravala, S.K. (deposition date: 2020-02-11, release date: 2020-07-22, Last modification date: 2023-10-11) |
Primary citation | Ravala, S.K.,Hopkins, J.B.,Plescia, C.B.,Allgood, S.R.,Kane, M.A.,Cash, J.N.,Stahelin, R.V.,Tesmer, J.J.G. The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding. J.Biol.Chem., 295:12635-12647, 2020 Cited by PubMed: 32661198DOI: 10.1074/jbc.RA120.014534 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.12 Å) |
Structure validation
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