6VSD

Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-((thiophen-2-ylthio)methyl)benzoic acid (fragment 13)

6VSD の概要

• エントリーDOI: 10.2210/pdb6vsd/pdb
• 分子名称: Dihydrofolate reductase, 3-(thiophen-2-ylsulfanylmethyl)benzoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: folate pathway, biosynthetic protein
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38082.97

構造登録者

Ribeiro, J.A.,Dias, M.V.B. (登録日: 2020-02-11, 公開日: 2020-07-15, 最終更新日: 2023-10-11)

• 主引用文献: Ribeiro, J.A.,Hammer, A.,Libreros-Zuniga, G.A.,Chavez-Pacheco, S.M.,Tyrakis, P.,de Oliveira, G.S.,Kirkman, T.,El Bakali, J.,Rocco, S.A.,Sforca, M.L.,Parise-Filho, R.,Coyne, A.G.,Blundell, T.L.,Abell, C.,Dias, M.V.B.; Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis.; Acs Infect Dis., 6:2192-2201, 2020; PubMed: 32603583; DOI: 10.1021/acsinfecdis.0c00263

実験手法

X-RAY DIFFRACTION (1.693 Å)