6VPJ

TPX2 residues 7-20 fused to Aurora A residues 116-389 C247V + C319V double mutant dephosphorylated, and in complex with AMP-PNP

Summary for 6VPJ

• Entry DOI: 10.2210/pdb6vpj/pdb
• Related PRD ID: PRD_900006
• Descriptor: TPX2 fragment - Aurora A kinase domain fusion, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: ser/thr kinase, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 34747.22

Authors

Lim, D.C.,Yaffe, M.B. (deposition date: 2020-02-03, release date: 2020-08-05, Last modification date: 2024-04-03)

• Primary citation: Lim, D.C.,Joukov, V.,Rettenmaier, T.J.,Kumagai, A.,Dunphy, W.G.,Wells, J.A.,Yaffe, M.B.; Redox priming promotes Aurora A activation during mitosis.; Sci.Signal., 13:-, 2020; PubMed: 32694171; DOI: 10.1126/scisignal.abb6707

Experimental method

X-RAY DIFFRACTION (2.1 Å)