6VO7
Crystal structure of PI3K-alpha Ras Binding Domain (RBD)
Summary for 6VO7
Entry DOI | 10.2210/pdb6vo7/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (2 entities in total) |
Functional Keywords | ras binding domain, oncogenic signaling, effector, oncoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16799.79 |
Authors | Carey, L.M.,Martinez, N.G.,Campbell, S. (deposition date: 2020-01-30, release date: 2021-02-03, Last modification date: 2023-10-11) |
Primary citation | Martinez, N.G.,Thieker, D.F.,Carey, L.M.,Rasquinha, J.A.,Kistler, S.K.,Kuhlman, B.A.,Campbell, S.L. Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3K alpha and PI3K gamma. J.Mol.Biol., 433:166838-166838, 2021 Cited by PubMed: 33539876DOI: 10.1016/j.jmb.2021.166838 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
Download full validation report