6VNZ
NMR solution structure of tamapin, mutant K20A
Summary for 6VNZ
| Entry DOI | 10.2210/pdb6vnz/pdb |
| NMR Information | BMRB: 30719 |
| Descriptor | Potassium channel toxin alpha-KTx 5.4 (1 entity in total) |
| Functional Keywords | tamapin mutant, csalpha/beta, sk channels, toxin |
| Biological source | Hottentotta tamulus (Eastern Indian scorpion) |
| Total number of polymer chains | 1 |
| Total formula weight | 3412.08 |
| Authors | del Rio Portilla, F.,Melchor Meneses, C.M.,Mayorga Flores, M. (deposition date: 2020-01-29, release date: 2020-07-29, Last modification date: 2024-11-06) |
| Primary citation | Mayorga-Flores, M.,Chantome, A.,Melchor-Meneses, C.M.,Domingo, I.,Titaux-Delgado, G.A.,Galindo-Murillo, R.,Vandier, C.,Del Rio-Portilla, F. Novel Blocker of Onco SK3 Channels Derived from Scorpion Toxin Tamapin and Active against Migration of Cancer Cells. Acs Med.Chem.Lett., 11:1627-1633, 2020 Cited by PubMed Abstract: Peptide-based therapy against cancer is a field of great interest for biomedical developments. Since it was shown that SK3 channels promote cancer cell migration and metastatic development, we started using these channels as targets for the development of antimetastatic drugs. Particularly, tamapin (a peptide found in the venom of the scorpion ) is the most specific toxin against the SK2 channel currently known. Considering this fact, we designed diverse tamapin mutants based on three different hypotheses to discover a new potent molecule to block SK3 channels. We performed studies to evaluate this new toxin derivative inhibitor of cancer cell migration. Our results can be used to generate a new tamapin-based therapy against cancer cells that express SK3 channels. PubMed: 32832033DOI: 10.1021/acsmedchemlett.0c00300 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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