6VND
Quaternary Complex of human dihydroorotate dehydrogenase (DHODH) with flavin mononucleotide (FMN), orotic acid and AG-636
6VND の概要
エントリーDOI | 10.2210/pdb6vnd/pdb |
分子名称 | Dihydroorotate dehydrogenase (quinone), mitochondrial, GLYCEROL, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-1H-benzotriazole-7-carboxylic acid, ... (11 entities in total) |
機能のキーワード | dhodh, oxidoreductase, fmn binding, inhibitor, mitochondria inner membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 42536.97 |
構造登録者 | |
主引用文献 | McDonald, G.,Chubukov, V.,Coco, J.,Truskowski, K.,Narayanaswamy, R.,Choe, S.,Steadman, M.,Artin, E.,Padyana, A.K.,Jin, L.,Ronseaux, S.,Locuson, C.,Fan, Z.P.,Erdmann, T.,Mann, A.,Hayes, S.,Fletcher, M.,Nellore, K.,Rao, S.S.,Subramanya, H.,Reddy, K.S.,Panigrahi, S.K.,Antony, T.,Gopinath, S.,Sui, Z.,Nagaraja, N.,Dang, L.,Lenz, G.,Hurov, J.,Biller, S.A.,Murtie, J.,Marks, K.M.,Ulanet, D.B. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol.Cancer Ther., 19:2502-2515, 2020 Cited by PubMed: 33082276DOI: 10.1158/1535-7163.MCT-20-0550 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.97 Å) |
構造検証レポート
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