6VN8
JAK2 JH1 in complex with baricitinib
Summary for 6VN8
Entry DOI | 10.2210/pdb6vn8/pdb |
Descriptor | Tyrosine-protein kinase JAK2, Baricitinib (3 entities in total) |
Functional Keywords | janus associated kinase, jak2, kinase domain, jh1, kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 73653.72 |
Authors | Davis, R.R.,Schonbrunn, E. (deposition date: 2020-01-29, release date: 2021-02-17, Last modification date: 2023-11-15) |
Primary citation | Davis, R.R.,Li, B.,Yun, S.Y.,Chan, A.,Nareddy, P.,Gunawan, S.,Ayaz, M.,Lawrence, H.R.,Reuther, G.W.,Lawrence, N.J.,Schonbrunn, E. Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof. J.Med.Chem., 64:2228-2241, 2021 Cited by PubMed: 33570945DOI: 10.1021/acs.jmedchem.0c01952 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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