6VLR

BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab

6VLR の概要

• エントリーDOI: 10.2210/pdb6vlr/pdb
• EMDBエントリー: 21232
• 分子名称: Envelope glycoprotein gp120, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• 機能のキーワード: hiv, antibody, fab, vaccine, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 14
• 化学式量合計: 334874.94

構造登録者

Cottrell, C.A.,Ward, A.B. (登録日: 2020-01-24, 公開日: 2020-06-24, 最終更新日: 2024-10-09)

主引用文献

Cottrell, C.A.,van Schooten, J.,Bowman, C.A.,Yuan, M.,Oyen, D.,Shin, M.,Morpurgo, R.,van der Woude, P.,van Breemen, M.,Torres, J.L.,Patel, R.,Gross, J.,Sewall, L.M.,Copps, J.,Ozorowski, G.,Nogal, B.,Sok, D.,Rakasz, E.G.,Labranche, C.,Vigdorovich, V.,Christley, S.,Carnathan, D.G.,Sather, D.N.,Montefiori, D.,Silvestri, G.,Burton, D.R.,Moore, J.P.,Wilson, I.A.,Sanders, R.W.,Ward, A.B.,van Gils, M.J.
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16:e1008753-e1008753, 2020

PubMed Abstract: The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown promise as vaccine candidates as they can induce potent autologous neutralizing responses in rabbits and non-human primates. In this study, monoclonal antibodies were isolated and characterized from rhesus macaques immunized with the BG505 SOSIP.664 trimer to better understand vaccine-induced antibody responses. Our studies reveal a diverse landscape of antibodies recognizing immunodominant strain-specific epitopes and non-neutralizing neo-epitopes. Additionally, we isolated a subset of mAbs against an epitope cluster at the gp120-gp41 interface that recognize the highly conserved fusion peptide and the glycan at position 88 and have characteristics akin to several human-derived broadly neutralizing antibodies.

PubMed: 32866207
DOI: 10.1371/journal.ppat.1008753

実験手法

ELECTRON MICROSCOPY (4.42 Å)