6VLD

Crystal structure of human alpha 1,6-fucosyltransferase, FUT8 bound to GDP and A2SGP

Summary for 6VLD

Entry DOI	10.2210/pdb6vld/pdb
Descriptor	Alpha-(1,6)-fucosyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ASPARAGINE, ... (6 entities in total)
Functional Keywords	fut8, fucosyltransferase, glycosyltransferase, n-glycan, core fucose, sh3 domain, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	230828.36
Authors	Jarva, M.A.,Dramicanin, M.,Lingford, J.P.,Mao, R.,John, A.,Goddard-Borger, E.D. (deposition date: 2020-01-23, release date: 2020-02-26, Last modification date: 2023-10-11)
Primary citation	Jarva, M.A.,Dramicanin, M.,Lingford, J.P.,Mao, R.,John, A.,Jarman, K.E.,Grinter, R.,Goddard-Borger, E.D. Structural basis of substrate recognition and catalysis by fucosyltransferase 8. J.Biol.Chem., 295:6677-6688, 2020 Cited by PubMed: 32220931 DOI: 10.1074/jbc.RA120.013291 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation