6VKD

Crystal Structure of Inhibitor JNJ-36689282 in Complex with Prefusion RSV F Glycoprotein

Summary for 6VKD

Entry DOI	10.2210/pdb6vkd/pdb
Descriptor	Prefusion RSV F (DS-Cav1), 1-cyclopropyl-3-({1-[3-(methylsulfonyl)propyl]-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	inhibitor, complex, viral protein
Biological source	Human respiratory syncytial virus More
Total number of polymer chains	1
Total formula weight	64255.68
Authors	McLellan, J.S. (deposition date: 2020-01-20, release date: 2020-05-27, Last modification date: 2023-10-11)
Primary citation	Vendeville, S.,Tahri, A.,Hu, L.,Demin, S.,Cooymans, L.,Vos, A.,Kwanten, L.,Van den Berg, J.,Battles, M.B.,McLellan, J.S.,Koul, A.,Raboisson, P.,Roymans, D.,Jonckers, T.H.M. Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus. J.Med.Chem., 63:8046-8058, 2020 Cited by PubMed: 32407115 DOI: 10.1021/acs.jmedchem.0c00226 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation