6VJE

Crystal structure of Pseudomonas aeruginosa penicillin-binding protein 3 (PBP3) complexed with ceftobiprole

6VJE の概要

• エントリーDOI: 10.2210/pdb6vje/pdb
• 分子名称: Peptidoglycan D,D-transpeptidase FtsI, (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: antibiotic target, complex, hydrolase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58936.94

構造登録者

van den Akker, F.,Kumar, V. (登録日: 2020-01-15, 公開日: 2020-03-11, 最終更新日: 2023-10-11)

• 主引用文献: Kumar, V.,Tang, C.,Bethel, C.R.,Papp-Wallace, K.M.,Wyatt, J.,Desarbre, E.,Bonomo, R.A.,van den Akker, F.; Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3.; Antimicrob.Agents Chemother., 64:-, 2020; PubMed: 32152075; DOI: 10.1128/AAC.00106-20

実験手法

X-RAY DIFFRACTION (1.76 Å)