6VIF
Human LRH-1 ligand-binding domain bound to agonist cpd 15 and fragment of coregulator TIF-2
Summary for 6VIF
Entry DOI | 10.2210/pdb6vif/pdb |
Descriptor | Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, N-[(8beta,11alpha,12alpha)-8-{[methyl(phenyl)amino]methyl}-1,6:7,14-dicycloprosta-1(6),2,4,7(14)-tetraen-11-yl]sulfuric diamide, ... (4 entities in total) |
Functional Keywords | ligand-binding domain, nuclear receptor, small molecule, agonist, nuclear protein, liver receptor homolog-1 |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 30521.32 |
Authors | Cato, M.L.,Ortlund, E.A. (deposition date: 2020-01-13, release date: 2020-06-10, Last modification date: 2023-10-11) |
Primary citation | Cornelison, J.L.,Cato, M.L.,Johnson, A.M.,D'Agostino, E.H.,Melchers, D.,Patel, A.B.,Mays, S.G.,Houtman, R.,Ortlund, E.A.,Jui, N.T. Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition. Bioorg.Med.Chem.Lett., 30:127293-127293, 2020 Cited by PubMed: 32631515DOI: 10.1016/j.bmcl.2020.127293 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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